Blogs

Tags:

The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment option for chronic weight-loss in addition to a reduced-calorie diet and exercising.

Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you ought to err to the side of caution and allow the FDA do its job and demand some research be done so the public knows the side effects and dangers of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on their medications.

Researchers found that participants taking this drug for the year, dropped a few pounds within one month and have kept the extra weight off throughout the 56 weeks of the study. Contrave is often a combination with the drugs naltrexone and bupropion, which seems to reflect a new trend of weight-loss drugs which can be made up of more than one active ingredient, which might make them more effective and safer.

Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that by using a combination of pills has become popular is the fact that as of right now there aren't long term prescription diet pills that have been licensed by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug could also raise blood pressure and heartbeat, and must not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure levels and heart rate and must not be used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients to the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.

Suboxone contains two drugs; buprenorphine and naloxone. The naloxone is irrelevant in the event the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is used correctly, the naloxone is destroyed inside liver right after uptake in the intestines and it has no therapeutic effect. Buprenorphine may be the active substance; it is absorbed underneath the tongue (and through the entire mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I manipulate this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I in addition have treated addicts who've had gastric bypass, where the first the main intestine is bypassed along with the stomach contents empty right into a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy in which the drug is taken up by the duodenum and transferred straight away to the liver with the portal vein, where it's quickly and completely destroyed. After gastric bypass naloxone can be adopted by areas of the intestine which aren't served with the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

Tags:

The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in grown-ups with a body mass index (BMI) of more than 27, given that they also suffer from weight-related medical issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment selection for chronic weight loss for people who are obese or are overweight and still have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a typical weight loss of four years old.1% in contrast to participants who were given placebos) within a 12- month period, while a different study involving patients with type 2 diabetes had a typical weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to shed pounds can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it you should err along the side of caution and allow the FDA do its job and demand some study be done in order that the public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies come in business to generate income and that they would say everything to keep people on their medications.

Researchers found that participants investing in this drug for a year, lost excess weight within 4 weeks and have kept the load off during the entire 56 weeks in the study. Contrave is really a combination from the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs which can be made up of multiple active ingredient, which might make them more effective and safer.

Combo-pilling could be the newest fad or better yet the newest into the future under scrutiny and so it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular may be the fact that by right now there are not any long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise hypertension and heartrate, and must not be used in individuals with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure level and heart rate and must not used in patients with uncontrolled high blood pressure level, along with by you are not heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients on the increased risk of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

New UCLA study on smokers with mental, drug, and alcohol problems

Tags:

The FDA announced the approval of your new fat loss drug on Sept. 11, 2014. The drug name is Contrave.

Using two separate drugs to lose weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the those who go through it you need to err assisting caution and let the FDA do its job and demand some study be done in order that the public recognizes the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to earn money and that they would say almost anything to keep people on his or her medications.

Researchers found out that participants investing in this drug for any year, dropped a few pounds within a month and have kept the weight off through the entire 56 weeks of the study. Contrave is often a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which might be made up of several active ingredient, which can make them more effective and safer.

Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is starting to become popular may be the fact that by right now there aren't any long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug also can raise blood pressure levels and heartbeat, and mustn't be used in people who have a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and heartbeat and must not be used in patients with uncontrolled high blood pressure levels, in addition to by you are not heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients which has a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients towards the increased chance of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for quitting smoking.

Most of the combinations that are used to enhance weight-loss involve an amphetamine plus an antidepressant. Phentermine and Prozac certainly are a popular combination that were around for some time, and even though it has been around stuffed to truly combine both the and try to get FDA approval to advertise it as a fat loss pill. Right there should raise some warning flag if the greedy pharmaceutical companies should not be involved in combining medications and selling them something should be wrong while using combination. In fairness there exists one fat loss combination pill that is in front of the FDA now Contrave?which couples naltrexone, accustomed to treat alcohol and abusing drugs, using the antidepressant bupropion (Wellbutrin, Zyban) it's been given the go ahead to move forward by an FDA advisory committee, but by yet hasn't been approved.