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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, so long as they also suffer from weight-related health problems such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to stopping smoking treatment.'Obesity continues to be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle which includes a reduced-calorie diet and exercise, Contrave provides another treatment selection for chronic weight management for people who are obese or are overweight and possess at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that contains a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% as opposed to participants who were given placebos) after a 12- month period, while a separate study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to lose weight naturally can be very effective there are combinations while watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it one should err along the side of caution and allow FDA do its job and demand some investigation be done so the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies have been in business to generate money and that they would say almost anything to keep people on their own medications.

Researchers found out that participants taking this drug for any year, lost excess weight within a month and have kept the weight off throughout the 56 weeks with the study. Contrave is often a combination of the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, which might make them more potent and safer.

Combo-pilling could be the newest fad or also the newest into the future under scrutiny and therefore it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills has become popular could be the fact that by right now there aren't long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications although some people might of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug could also raise hypertension and heart rate, and really should not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not used in patients with uncontrolled high blood pressure levels, and also by a person with heart-related and cerebrovascular (circulatory dysfunction impacting the mind) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

"This could be the first drug I'm mindful of that targets the two appetite and reward centres in the brain," he explained.