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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight reduction in addition to a reduced-calorie diet and exercise.

Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you ought to err along the side of caution and allow the FDA do its job and demand some study be done so the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on his or her medications.

Researchers found that participants taking this drug for any year, lost weight within a month and have kept the body weight off during the entire 56 weeks from the study. Contrave is often a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which may make them more effective and safer.

Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that as of right now there are no long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures are a side effect with Contrave and must not be taken in people with seizure disorders. The drug also can raise blood pressure levels and heartbeat, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high blood pressure levels, in addition to by you aren't heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

"This is the first drug I'm mindful of that targets both appetite and reward centres inside brain," he said.