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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in adults with a body mass index (BMI) of more than 27, so long as they also suffer from weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (hypertension).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination using a healthy lifestyle including a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had a normal weight loss of 4.1% as opposed to participants have been given placebos) within a 12- month period, while a separate study involving patients with diabetes type 2 had an average weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to lose weight naturally can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err along the side of caution and allow FDA do its job and demand some study be done so your public knows the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to earn money and that they would say almost anything to keep people on their own medications.

Researchers found that participants taking this drug for any year, dropped excess weight within a month and have kept the weight off through the entire 56 weeks from the study. Contrave can be a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which might be made up of several active ingredient, which might make them more effective and safer.

Combo-pilling will be the newest fad or even better the newest to come under scrutiny and for that reason it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular could be the fact that by right now there are not any long term prescription weight loss supplements that have been licensed by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and mustn't be taken in individuals with seizure disorders. The drug can also raise hypertension and heartrate, and must not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must not be used in patients with uncontrolled high blood pressure, and also by a person with heart-related and cerebrovascular (blood vessel dysfunction impacting mental performance) disease. Patients having a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased risk of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.

From a psychiatric point of view, evidence suggests that the ordinary neural mechanism for goal-directed behavior may be hijacked by the addiction, and malfunctions such that its ordinary functions are exaggerated and fixated on its object. An object creates a stimulus as well as the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).