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An article published on The American Journal on Addictions stated that expectant women who were dependent on opioids were strongly considering antagonist treatment, especially one which involves the use of naltrexone to combat their substance abuse disorder.

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Researchers found out that participants using this drug for a year, lost excess weight within 4 weeks and have kept the weight off through the 56 weeks of the study. Contrave can be a combination of the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs that are made up of many active ingredient, which might make them more effective and safer.

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Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but in the event the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed within the liver shortly after uptake in the intestines and has no therapeutic effect. Buprenorphine could be the active substance; it's absorbed within the tongue (and during the entire mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I purchased this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who have had gastric bypass, where the first the main intestine is bypassed and the stomach contents empty in to a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy the location where the drug is taken up through the duodenum and transferred right to the liver through the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be taken on by portions of the intestine which are not served from the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

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The Promises Treatment Centers, estimates that between five and 10 % of the patients at his doctors are treated with naltrexone. Those most likely to receive it are people with a history of early relapse—individuals who have been treated before and possess not had the opportunity to maintain sobriety for a lot more than four weeks.

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Researchers found that participants investing in this drug to get a year, dropped a few pounds within a month and have kept the body weight off during the entire 56 weeks with the study. Contrave is often a combination from the drugs naltrexone and bupropion, which seems to reflect a fresh trend of weight-loss drugs which can be made up of several active ingredient, which may make them more potent and safer.

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Seizures really are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise blood pressure level and heart rate, and mustn't be used in people with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must 't be used in patients with uncontrolled high blood pressure level, and also by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes with a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for quitting smoking.

"There were no signs and symptoms of depression or suicidal thoughts in trial participants," said Fujioka.

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Using two separate drugs to lose weight can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight loss and the individuals who go through it you need to err on the side of caution and let the FDA do its job and demand some investigation be done so that the public recognizes the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to generate income and that they would say almost anything to keep people on his or her medications.

Researchers found that participants using this drug for a year, dropped excess weight within four weeks and have kept the weight off through the entire 56 weeks of the study. Contrave is often a combination from the drugs naltrexone and bupropion, which seems to reflect a whole new trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more effective and safer.

Combo-pilling could be the newest fad or even better the newest to come under scrutiny and so it is just more publicly known recently, comb-pilling for weight reduction has been around since the eighties. The biggest reason that by using a combination of pills is now popular is the fact that since right now there are no long term prescription diet pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in people with seizure disorders. The drug could also raise blood pressure and heartbeat, and mustn't be used in people with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and heart rate and must stop used in patients with uncontrolled high hypertension, as well as by you are not heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.

Approving a drug with this many potentially lethal unwanted effects is inconsistent with the mission statement in the FDA. The power of the drug manufacturing lobby is blatantly evident within the approval of several drugs requiring 'post-marketing' studies that are clearly significant to overall drug safety inside the US.

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