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The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence in accordance with a news release by them on 10-12-2010.

Using two separate drugs to shed pounds can be very effective you can find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the those who go through it you need to err assisting caution and allow FDA do its job and demand some study be done in order that the public understands the side effects and dangers of the medications before we bring them. Keep in mind that drug companies come in business to earn money and that they would say anything to keep people on his or her medications.

Researchers discovered that participants using this drug for the year, lost weight within 4 weeks and have kept the weight off through the 56 weeks with the study. Contrave is really a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which are made up of multiple active ingredient, which might make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest into the future under scrutiny and so it is just more publicly known lately, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular may be the fact that at the time of right now there are not any long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations have been rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and really should not be taken in those with seizure disorders. The drug could also raise blood pressure and heartrate, and shouldn't be used in those with a history of cardiac arrest or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and pulse rate and must not be used in patients with uncontrolled high blood pressure, and also by you are not heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for smoking cessation.

Suboxone includes two drugs; buprenorphine and naloxone. The naloxone is irrelevant if the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone may cause instant withdrawal. When suboxone is employed correctly, the naloxone is destroyed in the liver right after uptake from the intestines and contains no therapeutic effect. Buprenorphine could be the active substance; it's absorbed beneath the tongue (and through the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I used this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have also treated addicts who've had gastric bypass, where the first part of the intestine is bypassed as well as the stomach contents empty in to a more distal the main small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy the location where the drug is taken up by the duodenum and transferred straight away to the liver by the portal vein, where it really is quickly and completely destroyed. After gastric bypass naloxone can be adopted by portions of the intestine which are not served from the portal system, causing blood numbers of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.