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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) of greater than 27, provided that they also have problems with weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment selection for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% rather than participants have been given placebos) after a 12- month period, while a separate study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to lose weight naturally can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err on the side of caution and allow FDA do its job and demand some study be done so the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on his or her medications.

Researchers found out that participants using this drug for a year, lost excess weight within 4 weeks and have kept the load off during the entire 56 weeks from the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of many active ingredient, that might make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular will be the fact that since right now there are no long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and must not be taken in people who have seizure disorders. The drug may also raise blood pressure level and heartrate, and must not be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high hypertension, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

--Participating in support groups that assist the family in the addict recover (like Al-Anon or Nar-Anon).