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The U.S. Food and Drug Administration has approved using Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) of more than 27, provided that they also experience weight-related health problems such as Tupe2 diabestes, high cholesterol and/or hypertension (blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder and as an aid to stop smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that features a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight management for people who are obese or are overweight and also have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical exercise. Results from a clinical trial that enrolled patients without diabetes indicated that patients had the average weight loss of four years old.1% rather than participants have been given placebos) within a 12- month period, while an outside study involving patients with type 2 diabetes had a typical weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to lose weight can be very effective you can find combinations before the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you should err on the side of caution and let the FDA do its job and demand some study be done in order that the public is aware of the side effects and hazards of the medications before we drive them. Keep in mind that drug companies come in business to generate money and that they would say everything to keep people on their medications.

Researchers discovered that participants taking this drug for the year, lost excess weight within four weeks and have kept the load off through the entire 56 weeks with the study. Contrave can be a combination from the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs that are made up of many active ingredient, which can make them more efficient and safer.

Combo-pilling could be the newest fad or in addition to this the newest ahead under scrutiny and therefore it is just more publicly known in recent months, comb-pilling to lose weight has been around since the eighties. The biggest reason that utilizing a combination of pills has become popular is the fact that by right now there aren't any long term prescription weight loss supplements that have been approved by the FDA other than orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug can also raise blood pressure and heartbeat, and really should not be used in people who have a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must 't be used in patients with uncontrolled high blood pressure level, in addition to by anyone with heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients for the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for smoking cessation.

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