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Evidence is increasing that every addiction without exception is related to difficulties with the brain's reward center, particularly the mesolimbic system. This area of the problem regulates reward responses in acquiring food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both when they malfunction and after they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the level of dopamine released in in reply to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed pounds can be very effective there are combinations before the FDA now awaiting approval. When dealing with weight reduction and the those who go through it you ought to err to the side of caution and allow FDA do its job and demand some investigation be done in order that the public recognizes the side effects and dangers of the medications before we drive them. Keep in mind that drug companies have been in business to earn money and that they would say everything to keep people on their own medications.

Researchers found that participants taking this drug for the year, dropped excess weight within four weeks and have kept the extra weight off during the entire 56 weeks from the study. Contrave is really a combination of the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs that are made up of many active ingredient, which might make them more efficient and safer.

Combo-pilling may be the newest fad or in addition to this the newest into the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for weight loss has been around since the eighties. The biggest reason that employing a combination of pills is starting to become popular could be the fact that at the time of right now there aren't long term prescription slimming capsules that have been approved by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations happen to be rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and really should not be taken in people with seizure disorders. The drug also can raise blood pressure levels and heartbeat, and mustn't be used in those with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure and pulse rate and must not used in patients with uncontrolled high hypertension, as well as by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients using a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes which has a boxed warning to alert physicians and patients to the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

"This may be the first drug I'm aware of that targets the two appetite and reward centres in the brain," he said.