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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in adults with a body mass index (BMI) of greater than 27, provided that they also have problems with weight-related health concerns such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave can be a combination of two FDA-approved drugs, naltrexone and bupropion, in a extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion qualifies to treat depression and seasonal affective disorder so that as an aid to stopping smoking treatment.'Obesity may be a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie eating and working out, Contrave provides another treatment selection for chronic weight-loss for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for just one year. All patients received lifestyle modification that contained a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes indicated that patients had a normal weight loss of four years old.1% rather than participants have been given placebos) after a 12- month period, while a separate study involving patients with diabetes had a typical weight loss of 2% over treatment with placebo at twelve months.

Using two separate drugs to lose weight naturally can be very effective you'll find combinations while watching FDA now awaiting approval. When dealing with weight reduction and the people who go through it one should err on the side of caution and allow FDA do its job and demand some study be done so the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on his or her medications.

Researchers found out that participants using this drug for a year, lost excess weight within 4 weeks and have kept the load off during the entire 56 weeks from the study. Contrave is a combination with the drugs naltrexone and bupropion, which appears to reflect a brand new trend of weight-loss drugs which might be made up of many active ingredient, that might make them more potent and safer.

Combo-pilling is the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that utilizing a combination of pills is becoming popular will be the fact that since right now there are no long term prescription slimming capsules that have been approved by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and must not be taken in people who have seizure disorders. The drug may also raise blood pressure level and heartrate, and must not be used in those with a history of heart attack or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise hypertension and heartrate and must stop used in patients with uncontrolled high hypertension, and also by you aren't heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients with a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.

--Participating in support groups that assist the family in the addict recover (like Al-Anon or Nar-Anon).

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On September 26, UCLA researcher reported the outcomes of a study, which indicated that Asians who are struggling with alcoholism will benefit especially from naltrexone, certainly one of three medications licensed by the U.S. Food and Drug Administration (FDA) for the treatment of alcoholism. Recent research has found out that a gene variant may predict naltrexone treatment success for alcoholism. About 50% of patients of Asian descent have a particular mutation that makes them prone to benefit from naltrexone, compared with about 20% of Caucasians and fewer than 5% of African Americans, said lead study author Lara Ray, an assistant professor of psychology and director with the UCLA Addictions Laboratory. The findings are currently available online ( within the journal Neuropsychopharmacology and you will be published within an upcoming print edition in the journal.

Using two separate drugs to shed weight can be very effective you'll find combinations in front of the FDA now awaiting approval. When dealing with fat loss and the people that go through it one should err along the side of caution and allow the FDA do its job and demand some investigation be done so the public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies will be in business to earn money and that they would say anything to keep people on their medications.

Researchers discovered that participants taking this drug for the year, lost excess weight within a month and have kept the body weight off through the entire 56 weeks with the study. Contrave is often a combination in the drugs naltrexone and bupropion, which seems to reflect a brand new trend of weight-loss drugs that are made up of many active ingredient, which may make them more effective and safer.

Combo-pilling may be the newest fad or even better the newest to come under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is becoming popular is the fact that since right now there aren't long term prescription weightloss pills that have been approved by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations are actually rejected or have yet to be licensed by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug could also raise blood pressure and heartbeat, and really should not be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise blood pressure and heartrate and must not be used in patients with uncontrolled high blood pressure, as well as by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting your brain) disease. Patients which has a history of cardiac arrest or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

The most common negative effects with Contrave include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.

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The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment choice for chronic weight reduction in addition to a reduced-calorie diet and exercise.

Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight reduction and the people who go through it you ought to err along the side of caution and allow the FDA do its job and demand some study be done so the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on his or her medications.

Researchers found that participants taking this drug for any year, lost weight within a month and have kept the body weight off during the entire 56 weeks from the study. Contrave is often a combination of the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs that are made up of multiple active ingredient, which may make them more effective and safer.

Combo-pilling may be the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills is starting to become popular will be the fact that as of right now there are no long term prescription weight loss supplements that have been licensed by the FDA other than orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications however some of the combinations are actually rejected or have yet to be authorized by the FDA.

Seizures are a side effect with Contrave and must not be taken in people with seizure disorders. The drug also can raise blood pressure levels and heartbeat, and shouldn't be used in people with a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high blood pressure levels, in addition to by you aren't heart-related and cerebrovascular (circulation dysfunction impacting mental performance) disease. Patients which has a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

"This is the first drug I'm mindful of that targets both appetite and reward centres inside brain," he said.