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The Food and Drug Administration, FDA, has approved the drug Vivitrol for the treatment of opioid dependence in accordance with a news release by them on 10-12-2010.

Using two separate drugs to lose weight can be very effective you'll find combinations before the FDA now awaiting approval. When dealing with weight-loss and the those who go through it you ought to err to the side of caution and allow the FDA do its job and demand some study be done so the public understands the side effects and hazards of the medications before we bring them. Keep in mind that drug companies have been in business to generate income and that they would say everything to keep people on their own medications.

Researchers found that participants using this drug for the year, lost weight within 4 weeks and have kept the body weight off through the 56 weeks of the study. Contrave is really a combination with the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of more than one active ingredient, that might make them more effective and safer.

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Seizures can be a side effect with Contrave and really should not be taken in people with seizure disorders. The drug also can raise blood pressure level and heart rate, and must not be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure level and heart rate and must not used in patients with uncontrolled high hypertension, along with by a person with heart-related and cerebrovascular (circulation dysfunction impacting the mind) disease. Patients with a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients on the increased chance of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant if the addict uses the medication properly, but if the tablet is dissolved in water and injected the naloxone can cause instant withdrawal. When suboxone is utilized correctly, the naloxone is destroyed within the liver right after uptake in the intestines and has no therapeutic effect. Buprenorphine could be the active substance; it is absorbed beneath the tongue (and through the mouth) but destroyed with the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation if the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who've had gastric bypass, in which the first section of the intestine is bypassed and the stomach contents empty in a more distal area of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the process with normal anatomy the place that the drug is taken up through the duodenum and transferred straight to the liver from the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken up by areas of the intestine which aren't served by the portal system, causing blood degrees of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.

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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in adults with a body mass index (BMI) of more than 27, provided that they also experience weight-related health concerns such as Tupe2 diabestes, high cholesterol levels and/or hypertension (high blood pressure levels).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is approved to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to stopping smoking treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director from the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle that includes a reduced-calorie dieting and exercise, Contrave provides another treatment option for chronic weight management for people who are obese or are overweight and still have at least one weight-related health.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a medical trial that enrolled patients without diabetes demonstrated that patients had a normal weight loss of four.1% as opposed to participants who have been given placebos) during a 12- month period, while a different study involving patients with diabetes type 2 symptoms had an average weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to shed weight can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the people that go through it you should err on the side of caution and let the FDA do its job and demand some research be done in order that the public knows the side effects and dangers of the medications before we drive them. Keep in mind that drug companies are in business to earn money and that they would say anything to keep people on the medications.

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The course of recovery, even for those taking the medications, centers more on talk and fewer on pills because while drugs like acamprosate and naltrexone help change brain chemistry, they just don't change minds. Once you're taking away the alcohol, sometimes while using successful utilization of prescribed medicine, the minds still need work. Alcoholics who slip in recovery and non-alcoholics drink for basically the same reason: It relieves social/physical/emotional tension. With alcoholics however, their health are programmed differently genetically and answer drinking with more drinking. So counseling or perhaps a 12-step meeting helps those abstinent keep from utilizing the first drink. Recovery has very little to do with stopping the drinking and the ones successful in recovery admit they're success is dependant on learning or relearning how you can manage life's tensions.

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